Innovate Biopharmaceuticals Announces Acceptance of Three Abstracts for the 2020 Digestive Disease Week (DDW) Conference
Highlighting Larazotide's Effect across the Gut-Vascular Barrier - a Fundamental Disease Mechanism in a Variety of Autoimmune and Inflammatory Diseases
Title: EXPLORING THE MECHANISMS OF LARAZOTIDE IN THE REGULATION OF THE TIGHT JUNCTION BARRIER (Abstract # 3348407)
Poster Session Title: Epithelial Junctions and Barrier Function
Title: CHIRALLY-MODIFIED LARAZOTIDE COMPOUND ANALOG #6 FACILITATES RECOVERY OF ISCHEMIC-INJURED PORCINE JEJUNUM VIA RE-ASSEMBLY OF INTRAEPITHELIAL TIGHT JUNCTIONS (Abstract # 3353776)
Poster Session Title: Molecular Mechanisms of Disease: Genetics, Signaling
Title: IN-VIVO ASSESSMENT OF CELIAC CLINICAL FORMULATION OF LARAZOTIDE IN THE PORCINE GASTROINTESTINAL TRACT USING A NOVEL ULTRAFILTRATION MODEL (Abstract # 3348457)
Poster Session Title: Celiac Disease and Gluten Related Disorders Pathogenesis
Executive Chairman of Innovate, Sandeep Laumas, M.D., stated, "Targeting the restoration of the gut-vascular barrier is an emerging field with exciting data from GI diseases, oncology and neurodegenerative diseases. Further data elucidating the mechanism of action and novel formulations of larazotide such as the development of chirally different larazotide molecules helps us address larazotide's pharmacology and bring the next generation of tight junction regulators for the treatment of autoimmune and inflammatory diseases."
"This exciting new work from our collaboration with Innovate is revealing not only novel mechanisms by which larazotide repairs interepithelial tight junctions in injured, or leaky, intestines, but also how to pharmaceutically ensure optimal stability of the peptide therapeutic within the intestine," remarked
Innovate is a clinical-stage biotechnology company focused on developing novel therapeutics for autoimmune and inflammatory diseases. Innovate's lead drug candidate, larazotide acetate, has a mechanism of action that renormalizes the dysfunctional intestinal barrier by decreasing intestinal permeability and reducing antigen trafficking, such as gliadin fragments in celiac disease, and bacterial toxins and immunogenic antigens in nonalcoholic steatohepatitis (
For more information, please visit www.innovatebiopharma.com.
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